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Senolytics Finally Cleared a Hard Endpoint. The Caveats Matter as Much as the Result.
For about a decade, senolytics have been the longevity field's most quotable idea: drugs that selectively kill senescent cells, the damaged cells that stop dividing but refuse to die and keep leaking inflammatory signals into the tissue around
Cervical Screening Can Now Start at Home. The Part Worth Understanding Is What Happens After
The FDA cleared the first at-home HPV self-collection kit in April, extending an approach that had been limited to clinics and pharmacies since 2024. The kit is for people 25 and older with an intact cervix who are
The Evidence That Air Pollution Reaches the Brain Keeps Getting Stronger. The Evidence That a Purifier Helps Is Thinner
A burden-of-proof meta-analysis published in Nature Aging worked through the studies linking long-term fine particulate exposure to dementia and applied a method designed to report the weakest defensible version of an association rather than the average
Taking Medications Away Turns Out to Be as Hard to Study as Adding Them. A Review of Nine Years of Trials Explains Why
A review published in June worked through the clinical trials of deprescribing in adults over 65 with polypharmacy, covering studies from 2017 through this year. Its central finding is easy to misread in either direction. Deprescribing had a neutral effect
Medicare Agreed to Pay for a Procedure That Lowers Blood Pressure by a Few Points. The Conditions Attached Are the Real Story
CMS finalised coverage for renal denervation last October, three years after the first device was approved, and the 2025 ACC and AHA blood pressure guidelines list it as an adjunctive option for uncontrolled hypertension. The procedure threads a catheter into
A New Class of Sleeping Pill Works by Switching Off Wakefulness. In Older Adults the Gains Are Real and Modest
A systematic review published in Sleep this May pooled the trials of dual orexin receptor antagonists in adults aged 65 and over, covering 2,235 treated patients against 1,409 controls. The results are worth quoting precisely, because precision is
There Are Now Two Hormone-Free Drugs for Hot Flashes. The Interesting Part Is How They Were Found
Elinzanetant was approved last October for moderate to severe hot flashes and night sweats due to menopause, joining fezolinetant, which arrived in 2023. Both are hormone-free. Both came out of the same piece of basic neuroscience rather than out
The Liver Disease Roughly a Third of Adults Have and Almost None Can Feel Now Has Two Approved Drugs
Fatty liver disease went from having no approved treatment to having two in about eighteen months. Resmetirom was cleared first, and semaglutide followed in August of last year for adults with metabolic dysfunction-associated steatohepatitis and moderate to advanced fibrosis,
Creatine Went From Gym Supplement to Brain Supplement. The Muscle Evidence Is Solid, the Brain Evidence Is Not Yet
A systematic review published in Nutrition Reviews this February pulled together six studies covering 1,542 adults aged 55 and over, about 56 percent of them women, and asked whether creatine does anything for cognition in later life. Five of
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