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The FDA Spent a Year Replacing Animal Tests With Chips and Models. Here Is What It Actually Changed
In April the FDA reported on the first year of its plan to reduce animal testing in drug development, and concluded that the foundations it set out had been met or exceeded. The list is concrete rather than aspirational: a
A New Antibiotic Beat the Old Standard by Twenty Points. The Harder Problem Is That Almost Nobody Wants to Build Them
The FDA approved Zaynich in June, an intravenous combination of cefepime with a compound called zidebactam, for complicated urinary tract infections and kidney infections caused by resistant gram-negative bacteria. In its phase 3 trial, involving 530 hospitalized patients, it
A Genetic Test Can Tell You How You Metabolize Some Drugs. The Number of Drugs Is Smaller Than the Brochure Suggests
The FDA maintains a public table of pharmacogenetic associations, updated most recently this month, listing the gene and drug pairs where the agency considers the evidence sufficient. It is organized into three tiers, and the tiering is the part worth
CPAP Did Not Reduce Heart Attacks in the Trials. Look at Who Actually Wore It and the Picture Changes
A meta-analysis published in March pooled eleven randomized trials covering 6,139 people with obstructive sleep apnea and asked whether treating it with CPAP reduces cardiovascular events. Across everyone randomized, the answer was no: the relative risk for major
The Big Testosterone Safety Trial Came Back Reassuring. The Clinics Selling It Are Answering a Different Question
A review published this June in the Journal of Endocrinological Investigation worked through what the TRAVERSE trial settled and what it did not. TRAVERSE randomized 5,246 men aged 45 to 80 who had confirmed low testosterone and elevated cardiovascular
NAD Is the Most Confidently Marketed Molecule in Longevity. The Human Evidence Is Thinner Than the Confidence
NAD boosters are now sold as capsules, as patches, and as intravenous drips in wellness clinics and med spas, usually at several hundred dollars a session. NPR examined the evidence behind the category this spring and found what most careful
Most People Who Break a Hip Were Treatable Beforehand. Almost None of Them Were Treated
A study of 1,103 patients aged 50 and over admitted to an Italian hospital with a fragility hip fracture, published this year, reported a number that is hard to read past. Just 7.4 percent had been receiving any
Washington Is About to Define Ultra-Processed Food. A Trial Already Tested Whether the Category Means Anything
The FDA and USDA sent a proposed federal definition of ultra-processed food to the Office of Management and Budget for final review in August, following a joint request for public comment that closed last autumn. For the first time
The Federal Dietary Guidelines Quietly Dropped Their Drink Limits. The Evidence They Were Based On Did Not Change
The 2025 to 2030 Dietary Guidelines for Americans were released in early January, and the alcohol section is now two sentences long. Where previous editions specified no more than two drinks a day for men and one for women, the
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