Featured Intelligence

Bird Flu in People: Small Numbers, and the Readiness Question Behind Them

Between early August 2025 and June of this year, three countries outside the United States reported twelve human H5N1 infections. Cambodia had eight, Bangladesh three, India one. Three people died. In every case the exposure traced back to sick or dead poultry, and in none of them did investigators identify person-to-person spread. The

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Fifteen Years of Trying to Change the Course of Osteoarthritis

Osteoarthritis affects tens of millions of American adults and has no treatment that alters what the disease does to a joint. Painkillers help with pain. Physical therapy helps with function. Injections help for a while. When the joint is far

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The Same Stool Sample, Seven Companies, Seven Different Answers

Researchers at the National Institute of Standards and Technology did something the direct-to-consumer microbiome industry had not done to itself. They took a single homogenized human stool sample, split it into identical portions, and sent them in triplicate

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Two Ways to Treat Multiple Food Allergies, and the Trial That Compared Them

For most of modern medicine's history, the only advice for a serious food allergy was avoidance and an epinephrine injector. Two approaches have changed that. Oral immunotherapy feeds the allergen in gradually escalating doses until the body stops

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Skipping the Factory: Making Cell Therapy Inside the Patient

CAR-T therapy works by taking a patient's own T cells, reprogramming them in a laboratory to recognize a target on cancer cells, growing them to large numbers, and infusing them back. It has produced durable remissions in

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A Genuinely New Blood Pressure Drug, for the People Current Ones Do Not Help

High blood pressure is the most common chronic condition in American adults and one of the best-served by existing medicine. There are five well-established drug classes, most of them inexpensive generics, and for the large majority of patients

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A Twice-Yearly Injection That Prevents HIV, and the Forty Dollar Question

Lenacapavir is given as an injection twice a year. Taken as prevention, it stops HIV infection at a rate the field describes in terms it rarely uses, and the World Health Organization recommended it for prevention in July 2025. For

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The RSV Vaccine Works Well in Year One. Year Three Is the Open Question.

Respiratory syncytial virus spent decades filed under childhood illness. In older adults it is a serious respiratory infection that fills hospital beds every winter, and until 2023 there was nothing to prevent it. Vaccines for adults over 60 arrived that

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Cold Plunges and Saunas: Separating the Evidence From the Enthusiasm

Few wellness practices have travelled further on less evidence than deliberate temperature exposure. Cold plunge tubs have become fixtures in gyms and in expensive homes, and sauna use is routinely described as a longevity intervention. The two are usually discussed

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