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The Ingredient Layer Underneath Your Prescriptions Is Being Rebuilt Slowly
A policy analysis published at the end of August put a number on something the pharmaceutical supply chain has known for years. The United States produced roughly a quarter of the world's active pharmaceutical ingredients in the early
Lab-Grown Neurons Have Reached a Pivotal Parkinson's Trial. Here Is What That Actually Means
A cell therapy made from pluripotent stem cells is now in a registrational, sham-surgery-controlled trial for Parkinson's disease. The therapy, bemdaneprocel, consists of dopamine-producing neuron precursors grown in a lab and implanted surgically into the
A Metabolic Drug Was Tested Against Alzheimer's Disease. The Result Is Worth Understanding Clearly
Two large late-stage trials, evoke and evoke+, tested oral semaglutide, the same active compound behind the widely used GLP-1 medicines, in people with early symptomatic Alzheimer's disease. After two years of treatment, the drug did not
Life Insurers Are Testing Biological Age. Federal Law Does Not Fully Protect You From That
Insurers have begun exploring epigenetic testing, the same kind of biological age technology increasingly discussed in longevity medicine, as a tool for evaluating life insurance applicants. At least one major life insurer has already partnered with a genomics company to
The Bacteria in Your Mouth May Be Talking to Your Brain. Researchers Are Taking It Seriously
Gum disease has long been treated as a localized dental problem, something to manage with better brushing and regular cleanings, separate from the rest of a person's health. That framing is looking increasingly incomplete. Researchers have identified a
Astronauts Are a Compressed Model of Aging, With One Genuinely Strange Twist
A few months in orbit produces changes in healthy, carefully screened astronauts that echo several recognized hallmarks of aging, shifts in stem cell function, gene expression, immune activity, and the gut microbiome, all compressed into a fraction of the time
Bariatric Surgery Still Outperforms GLP-1 Drugs, and the Reason Why Matters
GLP-1 drugs have dominated the conversation about obesity treatment for the past several years, but a large real-world comparison spanning more than thirty studies and over four hundred thousand patients found something worth sitting with: metabolic and bariatric
The First "Three-Parent" Babies Are Healthy, With One Complication Worth Understanding
Eight children born in the United Kingdom using a technique that combines genetic material from three people are now the subject of the first published, peer-reviewed results on how the approach actually performs in practice. The technique, mitochondrial donation,
Young Blood Plasma Therapy Sounds Like Science Fiction. The FDA Already Weighed In
A striking finding in aging mice, that exposure to young blood could improve muscle repair, brain function, and even extend lifespan, has quietly powered an entire corner of the longevity industry for over a decade. Clinics offer young donor plasma
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